Qon-teq^® offers the following products:

Electronic Lab Notebook

CERF-Notebook™ - The Electronic Lab Notebook (ELN) for Biology and Multidisciplinary Life Sciences. The Collaborative Electronic Research Framework™ (CERF) is a unique ELN solution designed specifically for scientists and R&D organizations. CERF-Notebook™
Provides a simple yet powerful interface for recording your research and accessing shared resources. Projects, documents, data, and notebooks are managed centrally on your secure CERF Server but can be created and utilized from anywhere that the user has an Internet connection. CERF-Notebook lets users organize their thoughts, ideas, and data into the real research story - much as a paper notebook does, but with the benefits of sharing, searching, digital signatures, templates, and more!

CERF is an extensible and scalable solution that meets needs and improves research performance in many organizations:

• Pharmaceutical companies and departments
  CERF is the Notebook and daily research environment (knowledge desktop) for your life scientists and integrates into your enterprise information infrastructure
• Biotechnology and service companies
  The CERF ELN and scientific content management solution may serve all of your needs out of the box, and CERF is readily tailored to support the scientists' activities and information workflows
• Government labs
  CERF provides the secure record-keeping and research collaboration platform needed for an internal department or for research projects distributed across multiple sites and diverse scientific units
• Academic departments and laboratories
  Our cross-platform CERF product may be the turnkey solution for your university lab, department, or core facility. CERF provides record-keeping (notebook) as well as shared information management and project organization in an adaptable, low-maintenance system designed for diverse users and workgroups

Sequence Data Management

Seqware DataCenter is a sequence data management platform, allowing to store, organize and compare user sequences, together with the whole GenBank, securely on a regular PC or on the network. Seqware automatically updates GenBank data on a daily basis and offers the following functionality:

• Store and manage your own sequences together with the whole GenBank
• Run BLAST locally. Store and reuse results
• Work with subsets of sequences
• Annotate sequences
• Run context searches

Sequence Data Analysis

Geneious Pro - integrated, cross-platform bioinformatics software suite for manipulating, finding, sharing, and exploring biological data such as DNA sequences or proteins, phylogenies, 3D structure information, publications, etc. It features sequence alignment and phylogenetic analysis, contig assembly, primer design and restriction analysis, access to NCBI and UniProt, BLAST, protein structure viewing, automated PubMed searching, and more. It even includes an API for creating your own plugins.

• Sequence Analysis
• Sequence Visualization
• Lab End Sequence Analysis
• Organize sequences and publications in a database
• Download protein sequences and gene sequences
• Interactive bioinformatics tutorials for teaching
• PubMed search

Analytical Application Servers

UFAE - The Unified Application Environment

The UFAE functions like an application server providing the end user with a menu of available applications. The end user chooses the desired functionality and the environment provides the client with the components to run the most current version. Once the software is loaded on the users computer, it can be accessed off-line. If newer versions are discovered, the server can update the client’s local version to assure concurrency:

• Desktop application server client functions offline
• End users have access to the most complete and current application tool set
• End users isolated from paradigm, functionality, and code changes
• Centralized distribution of new releases, bug fixes, and enhancements
• Centralized application security
• Standardized application paradigm minimizes the need for training and simplifies the learning curve
• Centralized application resources and training tools
• Built in application to application communication
• Standardized reporting tools
• Supports side by side application development
• Build distributed applications with state of the art programming tools and languages

Analysis Toolset and Data Reduction

BioPower™  - Empowers the screening scientist with a low impact, sensible, desktop data reduction and analysis tool that functions in both a structured, production HTS and an experimental assay development environment. This flexible application accepts data from any plate reader and computes results for any type of assay including high content and kinetic experiments. All of the data, results, and analysis settings are saved in a reusable workspace file:

• Enables fast, flexible data reduction for all readers and assays
• Displays computed data in real time including batch fitting of concentration curves, quality control results, and computational hit picking
• Easily import ancillary data like compound information, previous assay results, image data, etc.
• Generate and publish graphics rich reports with the built in reporting tools
• Operates independent of expensive, complex database systems
• 100% Microsoft™ .Net

Business Intelligence

Gene-Sensor.com - Offers manually curated and systematically edited information for business development. Find and evaluate customers, suppliers, financing partners, and competitors in a fast and intelligent way. All content is organized hierarchically and multiple powerful search options are available. Experts extract and transform content from documents into individual data records. The result: Direct & structured access to players & deals – ready for use in management decisions.

ri:val is the leading valuation solution for business developers, investors, CFOs, and CEOs in pharma and biotech. You can generate valuation results far beyond any error-prone spreadsheet calculation and quickly explore multiple scenarios. ri:val provides access to up-to-date industry data on drug development. Valuations of license contracts, drug development projects, pipelines, and biotech or pharma firms are easily done in a comprehensive, user-friendly framework.

• Standardized and comparable valuations
• Expert valuations
• Access to world-class valuation expertise
• Time saving
• Error free
• Backed by industry data
• Reproducible
• User friendly
• Guided valuation process
• Valuations easy to expand or to include in other valuations
• Professional visualization of results
• Full support for valuation questions by industry leaders

ri:val Features

• Project valuation
• License contract valuation
• Pipeline valuation
• Technology valuation
• Company valuation
• Risk adjusted net present value (rNPV)
• Real options valuation
• Monte Carlo simulations
• Scenario analysis
• Sensitivity analysis
• Export of valuation calculations into Excel
• Export of valuation results into Excel
• Automatic reports
• Export of all visualizations
• Export/import of projects/pipelines or companies
• Database of drug sales
• Database of drug development parameters (sales curve, costs, timelines, success rates per disease group)
• Database of epidemiological data

Protein-Ligand Docking

eHiTS: Electronic High Throughput Screening - Validation test runs demonstrate that eHiTS can reproduce X-ray structures with very high accuracy (low RMSD). eHiTS is not limited to local energy minima dihedral angle samples, it can find docking poses with unusual torsional angles if steric constraints require such conformation:

• Accurate
• Fast
• Easy to use, fully automated
• Customizable scoring function
• Parallel execution
• Guarantees to find the best solution

eHiTS LASSO: Ligand Activity in Surface Similarity Order - This new 3D ligand activity surfaced-based similarity tool gives users the power to quickly screen large datasets for structurally diverse active molecules. This proven scaffold-hopping capability is possible because eHiTS LASSO uses chemical features, not just 2D or 3D structural similarity, of active ligands to rapidly identify molecules with potentially similar activity.

• eHiTS LASSO provides a very easy-to-use training utility that will capture the chemical features of your active molecules
• Can be trained with a very small number of actives
• The eHiTS LASSO has been seamlessly integrated with the eHiTS docking program

De-Novo Design

SPROUT: De-novo ligand design software system - SPROUT 6.1 is the sixth generation of the successful, mature ligand design system. Through its use at various academic, government and industrial molecular modeling research centers, the software has proven to be successful for the generation of novel active ligand molecules.

Lead Optimization

SPROUT-LeadOpt: - SPROUT-LeadOpt builds on the very successful SPROUT program, however, unlike SPROUT, SPROUT-LeadOpt is not a de novo design tool, rather it is designed to produce structures that are similar to known lead molecules and have improved predicted binding affinities.

Synthetic Chemistry

CAESA: Computer Assisted Estimation of Synthetic Accessibility - CAESA automatically ranks sets of molecules according to their ease of synthesis and displays the synthesis route. Computational techniques to automatically generate large sets of structures are becoming increasingly widespread. Methods of automatically prioritizing these structures are central to the effective application of structure generation programs to solve practical problems.

Retrosynthetic Chemistry

ARChem: Automating Retrosynthetic Chemistry - An expert system aimed at helping chemists design viable synthetic routes for their target molecules. The knowledge of the expert system is automatically derived from reaction databases. The system also relies on databases of readily available starting materials for not breaking up the parts that have already been made.

Chemical Literature Data Extraction

CLiDE is a chemical literature data extraction tool - CLiDE is a chemistry intelligent equivalent of Optical Character Recognition (OCR) software. Just as an OCR tool can recognize characters from a scanned images of printed text, CLiDE can recognize structures, reactions and text from scanned images of printed chemistry literature. The software saves users hours of redrawing structures from printed material, as it transforms the 'images' into a 'real structures' that can then be input into databases.

eHITS is a trademark of SimBioSys, Inc. Biopower is a trademark of Exegetix, Inc., Geneious is a trademark of Biomatters, Ltd., CERF-Notebook is a trademark of Rescentris, Inc., Ri:val is a trademark of Avance GmbH